|Application ||WB, IHC-P, FC, E|
|Calculated MW||35046 Da|
|Antigen Region||4-38 aa|
|Other Names||Cyclin-dependent kinase 3, Cell division protein kinase 3, CDK3, CDKN3|
|Target/Specificity||This CDK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-38 amino acids from the N-terminal region of human CDK3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CDK3 Antibody (N-term Y19) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0- G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1- independent manner.|
|Tissue Location||Expressed in cancer cell lines and glioblastoma tissue.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0.
Bullrich, F., et al., Cancer Res. 55(6):1199-1205 (1995).
Meyerson, M., et al., EMBO J. 11(8):2909-2917 (1992).
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