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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   CDK3 Antibody (N-term Y19)   

CDK3 Antibody (N-term Y19)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CDK3 Antibody (N-term Y19) AP7519a
    Western blot analysis of CDK3(arrow) using rabbit polyclonal CDK3 Antibody (N-term Y19) (Cat. #). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CDK3 gene (Lane 2) (Origene Technologies).
  • IHC-P - CDK3 Antibody (N-term Y19) AP7519a
    Formalin-fixed and paraffin-embedded human lung carcinoma reacted with CDK3 Antibody (N-term Y19), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - CDK3 Antibody (N-term Y19) AP7519a
    Flow cytometric analysis of NCI-H292 cells using CDK3 Antibody (N-term Y19)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q00526
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 35046 Da
Antigen Region 4-38 aa
Additional Information
Gene ID 1018
Other Names Cyclin-dependent kinase 3, Cell division protein kinase 3, CDK3, CDKN3
Target/Specificity This CDK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-38 amino acids from the N-terminal region of human CDK3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCDK3 Antibody (N-term Y19) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDK3
Synonyms CDKN3
Function Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0- G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1- independent manner.
Tissue Location Expressed in cancer cell lines and glioblastoma tissue.
Research Areas
Citations (0)

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This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0.


Bullrich, F., et al., Cancer Res. 55(6):1199-1205 (1995).
Meyerson, M., et al., EMBO J. 11(8):2909-2917 (1992).

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$ 295.00
$ 99.00
Cat# AP7519a
(40 western blots)
Availability: In Stock
Bulk Size
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