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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CLK1 Antibody (N-term)   

CLK1 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CLK1 Antibody (N-term) AP7529a
    Western blot analysis of anti-hCLK1-C84 Pab (Cat. #AP7529a) in Y79 cell line lysate. hCLK1-C84(arrow) was detected using the purified Pab.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P49759
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 57291 Da
Antigen Region 70-99 aa
Additional Information
Gene ID 1195
Other Names Dual specificity protein kinase CLK1, CDC-like kinase 1, CLK1, CLK
Target/Specificity This CLK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 70-99 amino acids from the N-terminal region of human CLK1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCLK1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CLK1
Synonyms CLK
Function Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.
Cellular Location Nucleus.
Tissue Location Endothelial cells.
Research Areas
Citations (0)

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This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection.


Prasad, J., et al., Mol. Cell. Biol. 23(12):4139-4149 (2003). Talmadge, C.B., et al., Hum. Genet. 103(4):523-524 (1998). Hanes, J., et al., J. Mol. Biol. 244(5):665-672 (1994). Johnson, K.W., et al., J. Biol. Chem. 266(6):3402-3407 (1991). Ben-David, Y., et al., EMBO J. 10(2):317-325 (1991).

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$ 295.00
$ 99.00
Cat# AP7529a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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