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MOK Antibody (C-term)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP7543b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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MOK Antibody (C-term) - Product info | |
| Application | IHC, WB
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| Primary Accession | Q9UQ07 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 48014 Da |
MOK Antibody (C-term) - Additional info | |
| Gene ID 5891 | |
| Other Names MOK; RAGE; RAGE1; MAPK/MAK/MRK overlapping kinase; MOK protein kinase; Renal tumor antigen 1 | |
| Target/Specificity This MOK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 385~415 amino acids from the C-terminal region of human MOK. | |
| Dilution IHC~~1:50~100 WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions MOK Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
MOK Antibody (C-term) - Protein Information | |
| Name MOK | |
| Synonyms RAGE, RAGE1 | |
| Function Able to phosphorylate several exogenous substrates and to undergo autophosphorylation (By similarity) | |
| Cellular Location Cytoplasm (By similarity). | |
| Tissue Location Expressed in heart, brain, lung, kidney, and pancreas, and at very low levels in placenta, liver and skeletal muscle. Detected in retina | |
MOK Antibody (C-term) - Related products
AP6910c: RAGE Antibody (Center)
AP7543b: MOK Antibody (C-term)
DC07951: Human RAGE cDNA Clone
LY10124a: RAGE Over-expression Lysate
MOK Antibody (C-term) - Application data
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Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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MOK Antibody (S392) (Cat. #AP7543b) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the MOK antibody detected the MOK protein (arrow).
MOK Antibody (C-term) - Research Areas
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.
REFERENCES
Miyata, Y., et al., Genes Cells 4(5):299-309 (1999). Gaugler, B., et al., Immunogenetics 44(5):323-330 (1996).
