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DYRK1A Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
United StatesOrdering Information
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(40 western blots)
$ 265.00email & fax$ 251.75online
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(8 western blots)
$ 95.00email & fax$ 90.25online
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DYRK1A Antibody (N-term) - Product info
|Application ||WB, IHC|
|Other Accession||Q2TAE3, Q63470, Q61214|
|Predicted||Mouse, Rat, Xenopus|
|Calculated MW||85584 Da|
DYRK1A Antibody (N-term) - Additional info
|Gene ID 1859|
DYRK1A; DYRK; MNB; MNBH; Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual specificity YAK1-related kinase; HP86; Protein kinase minibrain homolog
This DYRK1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-136 amino acids from the N-terminal region of human DYRK1A.
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
DYRK1A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
DYRK1A Antibody (N-term) - Protein Information
|Synonyms DYRK, MNB, MNBH|
May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1, SRSF6 and SIRT1.
Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney
DYRK1A Antibody (N-term) - Related products
DYRK1A Antibody (N-term) - Research Areas
Western blot analysis of DYRK1A Antibody (N-term) (Cat.#AP7555a) in 293 cell line lysates (35ug/lane). DYRK1A (arrow) was detected using the purified Pab.
DYRK1A Antiboty (N-term) (Cat.#AP7555a) immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the DYRK1A Antiboty (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Provided below are standard protocols that you may find useful for product applications.
DYRK1A is a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. The DYRK1A gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome.
Adayev,T., Biochemistry 46 (25), 7614-7624 (2007)
Chang,H.S., Int. J. Cancer 120 (11), 2377-2385 (2007)
Alvarez,M., Mol. Biol. Cell 18 (4), 1167-1178 (2007)
Wissing,J., Mol. Cell Proteomics 6 (3), 537-547 (2007)