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DYRK1A Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

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United States
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Ordering Information
Catalog # SizeAvailability Price  
AP7555a 400 µl
(40 western blots)
In Stock
$ 265.00email & fax$ 251.75online
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AP7555a-ev 80 µl
(8 western blots)
In Stock
$ 95.00email & fax$ 90.25online
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DYRK1A Antibody (N-term) - Product info

Application
  • Applications Legend:
  • WB=Western Blotting
  • IP=Immunoprecipitation
  • IHC-P=Immunohistochemistry (Paraffin)
  • IF-IC=Immunofluorescence (Immunocytochemistry)
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC
Primary AccessionQ13627
Other AccessionQ2TAE3, Q63470, Q61214
ReactivityHuman
PredictedMouse, Rat, Xenopus
IsotypeRabbit Ig
Calculated MW85584 Da

DYRK1A Antibody (N-term) - Additional info

Gene ID 1859
Other Names
DYRK1A; DYRK; MNB; MNBH; Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual specificity YAK1-related kinase; HP86; Protein kinase minibrain homolog
Target/Specificity
This DYRK1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-136 amino acids from the N-terminal region of human DYRK1A.
Dilution
WB~~1:1000
IHC~~1:50~100
Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Storage
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions
DYRK1A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.

DYRK1A Antibody (N-term) - Protein Information

Name DYRK1A
Synonyms DYRK, MNB, MNBH
Function
May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1, SRSF6 and SIRT1.
Cellular Location
Nucleus speckle.
Tissue Location
Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney

DYRK1A Antibody (N-term) - Related products

AP19429b: Mouse Dyrk1a Antibody(C-term)

AP7555c: DYRK1A Antibody (Center)

BP19429b: Mouse Dyrk1a Antibody (C-term) Blocking Peptide

BP7555a: DYRK1A Antibody (N-term) Blocking Peptide

BP7555c: DYRK1A Antibody (Center) Blocking Peptide

DYRK1A Antibody (N-term) - Research Areas

Application data

  • WB - DYRK1A Antibody (N-term) AP7555a

    Western blot analysis of DYRK1A Antibody (N-term) (Cat.#AP7555a) in 293 cell line lysates (35ug/lane). DYRK1A (arrow) was detected using the purified Pab.

  • IHC - DYRK1A Antibody (N-term) AP7555a

    DYRK1A Antiboty (N-term) (Cat.#AP7555a) immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the DYRK1A Antiboty (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.

  • WB - DYRK1A Antibody (N-term) AP7555a
  • IHC - DYRK1A Antibody (N-term) AP7555a

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BACKGROUND

DYRK1A is a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. The DYRK1A gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome.

REFERENCES

Adayev,T., Biochemistry 46 (25), 7614-7624 (2007)
Chang,H.S., Int. J. Cancer 120 (11), 2377-2385 (2007)
Alvarez,M., Mol. Biol. Cell 18 (4), 1167-1178 (2007)
Wissing,J., Mol. Cell Proteomics 6 (3), 537-547 (2007)