- CITATIONS: 1
|Application ||WB, FC, E|
|Calculated MW||24722 Da|
|Other Names||Superoxide dismutase [Mn], mitochondrial, SOD2|
|Target/Specificity||This SOD2 antibody is generated from rabbits immunized with human recombinant SD protein.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SOD2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.|
|Cellular Location||Mitochondrion matrix.|
Provided below are standard protocols that you may find useful for product applications.
SOD2 is a member of the iron/manganese superoxide dismutase family. It is a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer.
Fabre,E.E., Am. J. Clin. Nutr. 87 (5), 1504-1512 (2008) Kaewpila,S., Cancer Res. 68 (8), 2781-2788 (2008) Flekac,M., (er) BMC Med. Genet. 9, 30 (2008)
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