|Application ||WB, IHC-P, E|
|Calculated MW||145234 Da|
|Antigen Region||907-936 aa|
|Other Names||Ras-specific guanine nucleotide-releasing factor 1, Ras-GRF1, Guanine nucleotide-releasing protein, GNRP, Ras-specific nucleotide exchange factor CDC25, RASGRF1, CDC25, GNRP, GRF1|
|Target/Specificity||This RASGRF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 907-936 amino acids from human RASGRF1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RASGRF1 Antibody (S929) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CDC25, GNRP, GRF1|
|Function||Promotes the exchange of Ras-bound GDP by GTP.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
RASGRF1 is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. Studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory.
Iguchi,T., Int. J. Oncol. 31 (2), 285-291 (2007)
Holmes,R., Mol. Cell. Biol. 26 (24), 9564-9570 (2006)
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