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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MCSF Receptor (CSF1R) Antibody (C-term)   

MCSF Receptor (CSF1R) Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - MCSF Receptor (CSF1R) Antibody (C-term) AP7604b
    Western blot analysis of anti-CSF1R Pab (Cat. #AP7604b) in human placenta. CSF1R (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
  • WB - MCSF Receptor (CSF1R) Antibody (C-term) AP7604b
    Western blot analysis of CSF1R (arrow) using rabbit polyclonal CSF1R Antibody (C-term)(Cat.#AP7604b). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CSF1R gene (Lane 2) (Origene Technologies).
  • FC - MCSF Receptor (CSF1R) Antibody (C-term) AP7604b
    MCSF Receptor (CSF1R) Antibody (C-term) (Cat. #AP7604b) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
  • IHC-P - MCSF Receptor (CSF1R) Antibody (C-term) AP7604b
    Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with CSF1R Antibody (C-term) (Cat.#AP7604b), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P07333
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 107984 Da
Antigen Region 940-971 aa
Additional Information
Gene ID 1436
Other Names Macrophage colony-stimulating factor 1 receptor, CSF-1 receptor, CSF-1-R, CSF-1R, M-CSF-R, Proto-oncogene c-Fms, CD115, CSF1R, FMS
Target/Specificity This MCSF Receptor (CSF1R) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 940-971 amino acids from the C-terminal region of human MCSF Receptor (CSF1R).
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMCSF Receptor (CSF1R) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CSF1R
Synonyms FMS
Function Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP- 1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Expressed in bone marrow and in differentiated blood mononuclear cells
Research Areas
Citations (0)

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CSF1R is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. This protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in the gene encoding CSF1R have been associated with a predisposition to myeloid malignancy.


Follows, G.A., et al., EMBO J. 22(11):2798-2809 (2003).
Riccioni, R., et al., Leukemia 17(1):98-113 (2003).
Zhu, K., et al., Biochem. Biophys. Res. Commun. 297(5):1211-1217 (2002).
Ide, H., et al., Proc. Natl. Acad. Sci. U.S.A. 99(22):14404-14409 (2002).
Flick, M.B., et al., J. Cell. Biochem. 85(1):10-23 (2002).

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$ 295.00
$ 99.00
Cat# AP7604b
(40 western blots)
Availability: In Stock
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