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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PCSK2 Antibody (Center)   

PCSK2 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PCSK2 Antibody (Center) AP7617C
    Western blot analysis of PCSK2 Antibody (Center) (Cat.#AP7617c) in 293(lane 1), K562(lane 2) cell line lysates (35ug/lane). PCSK2 (arrow) was detected using the purified Pab.
  • IHC-P - PCSK2 Antibody (Center) AP7617C
    Formalin-fixed and paraffin-embedded human brain tissue reacted with PCSK2 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - PCSK2 Antibody (Center) AP7617C
    PCSK2 Antibody (Center) (Cat. #AP7617c) flow cytometry analysis of K562 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P16519
Other Accession P28841, Q03333, P21661, Q9GLR0
Reactivity Human
Predicted Bovine, Mouse, Pig, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 70565 Da
Antigen Region 318-346 aa
Additional Information
Gene ID 5126
Other Names Neuroendocrine convertase 2, NEC 2, KEX2-like endoprotease 2, Prohormone convertase 2, Proprotein convertase 2, PC2, PCSK2, NEC2
Target/Specificity This PCSK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 318-346 amino acids from the Central region of human PCSK2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPCSK2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PCSK2
Synonyms NEC2
Function Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells.
Cellular Location Cytoplasmic vesicle, secretory vesicle. Note=Localized in the secretion granules
Research Areas
Citations (0)

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PCSK2 belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This protein is a proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. The protein is also known to cleave proopiomelanocortin, proenkephalin, prodynorphin and proluteinizing-hormone-releasing hormone.


Leak,T.S., Keene,K.L. Mol. Genet. Metab. 92 (1-2), 145-150 (2007)
Shen,X., Li,Q.L. Am. J. Physiol. Endocrinol. Metab. 288 (1), E236-E245 (2005)
Tzimas,G.N., Chevet,E. BMC Cancer 5, 149 (2005)
Seidah,N.G., Mattei,M.G. Genomics 11 (1), 103-107 (1991)

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$ 295.00
$ 99.00
Cat# AP7617C
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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