|Application ||WB, IHC-P, FC, E|
|Calculated MW||54739 Da|
|Antigen Region||451-479 aa|
|Other Names||Phospholipid transfer protein, Lipid transfer protein II, PLTP|
|Target/Specificity||This PLTP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 451-479 amino acids from the C-terminal region of human PLTP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Precautions||PLTP Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Essential for the transfer of excess surface lipids from triglyceride-rich lipoproteins to HDL, thereby facilitating the formation of smaller lipoprotein remnants, contributing to the formation of LDL, and assisting in the maturation of HDL particles. PLTP also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion. Two distinct forms of PLTP exist in plasma: an active form that can transfer PC from phospholipid vesicles to high-density lipoproteins (HDL), and an inactive form that lacks this capability.|
|Tissue Location||Wide tissue distribution. Placenta > pancreas > lung > kidney > heart > liver > skeletal muscle > brain|
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Provided below are standard protocols that you may find useful for product applications.
PLTP is one of at least two lipid transfer proteins found in human plasma. The protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism.
Moerland,M., Samyn,H. Arterioscler. Thromb. Vasc. Biol. 28 (7), 1277-1282 (2008)
Albers,J.J., Wolfbauer,G. Biochim. Biophys. Acta 1258 (1), 27-34 (1995)
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