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XPOT Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - XPOT Antibody (N-term) AP7632a
    Western blot analysis of XPOT antibody (N-term) (Cat.#AP7632a) in Ramos cell line lysates (35ug/lane). XPOT (arrow) was detected using the purified Pab.
  • IHC-P - XPOT Antibody (N-term) AP7632a
    Formalin-fixed and paraffin-embedded human lymph with XPOT Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O43592
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 109964 Da
Antigen Region 137-166 aa
Additional Information
Gene ID 11260
Other Names Exportin-T, Exportin(tRNA), tRNA exportin, XPOT
Target/Specificity This XPOT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 137-166 amino acids from the N-terminal region of human XPOT.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsXPOT Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP- bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Cellular Location Nucleus. Cytoplasm. Note=Nuclear, once bound to tRNA and Ran the complex translocates to the cytoplasm Shuttles between the nucleus and the cytoplasm
Research Areas
Citations (0)

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XPOT is a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN.


Li,S. , RNA Biol 3 (4), 145-149 (2006)
Suzuki,T., Biomed. Res. 27 (2), 89-92 (2006)
Kuersten,S., Mol. Cell. Biol. 22 (16), 5708-5720 (2002)

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Cat# AP7632a
(40 western blots)
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