|Application ||WB, IHC-P, E|
|Calculated MW||29557 Da|
|Antigen Region||146-177 aa|
|Other Names||Carbonic anhydrase 3, Carbonate dehydratase III, Carbonic anhydrase III, CA-III, CA3|
|Target/Specificity||This CA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 146-177 amino acids from the Central region of human CA3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CA3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Reversible hydration of carbon dioxide.|
|Tissue Location||Muscle specific.|
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Provided below are standard protocols that you may find useful for product applications.
Carbonic anhydrase III (CAIII) is a member of carbonic anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and are differentially expressed in a number of cell types. The expression of the CA3 gene is strictly tissue specific and present at high levels in skeletal muscle and much lower levels in cardiac and smooth muscle. A proportion of carriers of Duchenne muscle dystrophy have a higher CA3 level than normal.
Du,A.L., Autoimmunity 42 (3), 209-215 (2009)
Dai,H.Y., Mol. Carcinog. 47 (12), 956-963 (2008)
Gailly,P., Kidney Int. 74 (1), 52-61 (2008)
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