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NAB2 Antibody (Center)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP7635c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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- Backgrounds
NAB2 Antibody (Center) - Product info | |
| Application | WB
|
| Primary Accession | Q15742 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 56594 Da |
NAB2 Antibody (Center) - Additional info | |
| Gene ID 4665 | |
| Other Names NAB2; MADER; NGFI-A-binding protein 2; EGR-1-binding protein 2; Melanoma-associated delayed early response protein | |
| Target/Specificity This NAB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116~146 amino acids from the Center region of human NAB2. | |
| Dilution WB~~1:50~100WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions NAB2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
NAB2 Antibody (Center) - Protein Information | |
| Name NAB2 | |
| Synonyms MADER | |
| Function Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity) | |
| Cellular Location Nucleus (By similarity). Note=Isoform 2 is not localized to the nucleus (By similarity) | |
| Tissue Location Widely expressed at low levels. Highly expressed in melanoma cell lines | |
NAB2 Antibody (Center) - Related products
AP7635a: NAB2 Antibody (N-term)
AP7635c: NAB2 Antibody (Center)
DC08531: Human NAB2 cDNA Clone
LY11923a: NAB2 Over-expression Lysate
NAB2 Antibody (Center) - Application data
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Western blot analysis of NAB2 antibody (Center) (Cat.#AP7635c) in A375 cell line lysates (35ug/lane). NAB2 (arrow) was detected using the purified Pab.
NAB2 Antibody (Center) - Research Areas
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
NAB2 is a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by this protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex.
REFERENCES
Srinivasan,R., J. Biol. Chem. 281 (22), 15129-15137 (2006) Kumbrink,J., J. Biol. Chem. 280 (52), 42785-42793 (2005) Lucerna,M., J. Biol. Chem. 278 (13), 11433-11440 (2003)
