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RET Antibody (C-term T1078)

Purified Rabbit Polyclonal Antibody (Pab)

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Ordering Information
Catalog # SizeAvailability Price  
AP7669B 400 µl
(40 western blots)
In Stock
$ 265.00email & fax$ 251.75online
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AP7669B-ev 80 µl
(8 western blots)
In Stock
$ 95.00email & fax$ 90.25online
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  • Specification
  • Citations : 1
  • Reviews
  • Protocols
  • Background

RET Antibody (C-term T1078) - Product info

Application
  • Applications Legend:
  • WB=Western Blotting
  • IP=Immunoprecipitation
  • IHC-P=Immunohistochemistry (Paraffin)
  • IF-IC=Immunofluorescence (Immunocytochemistry)
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary AccessionP07949
ReactivityHuman
IsotypeRabbit Ig
Calculated MW124319 Da

RET Antibody (C-term T1078) - Additional info

Gene ID 5979
Other Names
RET; CDHF12; CDHR16; PTC; RET51; Proto-oncogene tyrosine-protein kinase receptor Ret; Cadherin family member 12; Proto-oncogene c-Ret; Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment
Target/Specificity
This RET antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1063-1093 amino acids from the C-terminal region of human RET.
Dilution
WB~~1:1000
Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Storage
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions
RET Antibody (C-term T1078) is for research use only and not for use in diagnostic or therapeutic procedures.

RET Antibody (C-term T1078) - Protein Information

Name RET
Synonyms CDHF12, CDHR16, PTC, RET51
Function
Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut- associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration.
Cellular Location
Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein

RET Antibody (C-term T1078) - Related products

AM1869a: RET Antibody (Ascites)

AP12639A: RET Antibody

AP7669a: RET Antibody (N-term C166)

AP7669c: RET Antibody (N-term Q28)

AP7669d: RET Antibody (C-term L1027)

BP7669a: RET Antibody (N-term C166) Blocking Peptide

BP7669b: RET Antibody (C-term T1078) Blocking Peptide

BP7669c: RET Antibody (N-term Q28) Blocking Peptide

BP7669d: RET Antibody (C-term L1027) Blocking Peptide

AO1129a: RET Antibody

AO1138a: RET Antibody

AG1168: Ret (extracellular) Antibody

AP50300: Phospho-Ret (Tyr1062) Antibody

RET Antibody (C-term T1078) - Research Areas

  • siRNA nanoformulation against the ret/PTC1 junction oncogene is efficient in an in vivo model of papillary thyroid carcinoma. Author : de Martimprey H, Bertrand JR, Fusco A, Santoro M, Couvreur P, Vauthier C, Malvy C.
    Nucleic Acids Res. 2008 Jan;36(1):e2. Epub 2007 Dec 13.
    PubMed® Id : 18079153

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BACKGROUND

RET, a member of the cadherin superfamily, is one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This protein plays a crucial role in neural crest development, and the gene can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations i are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma.

REFERENCES

Da Silva, A.M., et al., J. Clin. Endocrinol. Metab. 88(11):5438-5443 (2003).
McWhinney, S.R., et al., J. Clin. Endocrinol. Metab. 88(10):4911-4916 (2003).
D'Alessio, A., et al., Endocrinology 144(10):4298-4305 (2003).
Soares, P., et al., Oncogene 22(29):4578-4580 (2003).
Punales, M.K., et al., J. Clin. Endocrinol. Metab. 88(6):2644-2649 (2003).