|Application ||WB, IHC-P, FC, E|
|Calculated MW||58254 Da|
|Antigen Region||13-44 aa|
|Other Names||Tyrosine-protein kinase FRK, FYN-related kinase, Nuclear tyrosine protein kinase RAK, Protein-tyrosine kinase 5, FRK, PTK5, RAK|
|Target/Specificity||This FRK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-44 amino acids from the N-terminal region of human FRK.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FRK Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.|
|Cellular Location||Cytoplasm. Nucleus. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery|
|Tissue Location||Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth.
Meyer, T., et al., Int. J. Cancer 104(2):139-146 (2003).
Craven, R.J., et al., Cancer Res. 55(18):3969-3972 (1995).
Cance, W.G., et al., Cell Growth Differ. 5(12):1347-1355 (1994).
Cance, W.G., et al., Int. J. Cancer 54(4):571-577 (1993).
Lee, J., et al., Gene 138 (1-2), 247-251 (1994).
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