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IPF Antibody (S66)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AP7740e | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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IPF Antibody (S66) - Product info | |
| Application | WB
|
| Primary Accession | P52945 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 30771 Da |
IPF Antibody (S66) - Additional info | |
| Gene ID 3651 | |
| Other Names PDX1; IPF1; Pancreas/duodenum homeobox protein 1; Glucose-sensitive factor; Insulin promoter factor 1; Insulin upstream factor 1; Islet/duodenum homeobox-1; Somatostatin-transactivating factor 1 | |
| Target/Specificity This IPF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50~80 amino acids surrounding S66 of human IPF. | |
| Dilution WB~~1:1000WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions IPF Antibody (S66) is for research use only and not for use in diagnostic or therapeutic procedures. | |
IPF Antibody (S66) - Protein Information | |
| Name PDX1 | |
| Synonyms IPF1, STF1 | |
| Function Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3' During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell | |
| Cellular Location Nucleus. Cytoplasm, cytosol (By similarity). | |
| Tissue Location Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells) | |
IPF Antibody (S66) - Related products
AP3617a: Phospho-IPF-pT11 Antibody
AP3618a: Phospho-IPF-pS66 Antibody
AP3669a: Phospho-PDX1-T11 Antibody
AP7740a: PDX1 Antibody (N-term)
AP7740b: IPF Antibody (C-term)
BP3617a: Phospho-IPF-pT11 Antibody Blocking Peptide
BP3618a: Phospho-IPF-pS66 Antibody Blocking Peptide
BP3669a: Phospho-PDX1-T11 Antibody Blocking Peptide
BP7740a: IPF Antibody (N-term) Blocking Peptide
BP7740b: IPF Antibody (C-term) Blocking Peptide
IPF Antibody (S66) - Application data
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Ipf Antibody (pS66) (Cat. #AP7740e) western blot analysis in Daudi cell line lysates (35ug/lane).This demonstrates the PDX1 antibody detected the PDX1 protein (arrow).
IPF Antibody (S66) - Research Areas
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BACKGROUND
IPF is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. This nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
REFERENCES
Ma,J., Carcinogenesis 29 (7), 1327-1333 (2008) Watada,H., Biochem. Biophys. Res. Commun. 229 (3), 746-751 (1996)
