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SEMA3A Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q14563 |
| Other Accession | Q63548, O08665, Q90607 |
| Reactivity | Human |
| Predicted | Chicken, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 88889 Da |
| Antigen Region | 535-566 aa |
| Gene ID | 10371 |
|---|---|
| Other Names | Semaphorin-3A, Semaphorin III, Sema III, SEMA3A, SEMAD |
| Target/Specificity | This SEMA3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 535-566 amino acids from the Central region of human SEMA3A. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SEMA3A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SEMA3A |
|---|---|
| Synonyms | SEMAD |
| Function | Involved in the development of the olfactory system and in neuronal control of puberty. Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1. |
| Cellular Location | Secreted. |
| Tissue Location | Expressed in the dorsal root ganglia. |
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Provided below are standard protocols that you may find useful for product applications.
Background
SEMA3A is a member of the semaphorin family with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease.
References
Narazaki,M., Blood 111 (8), 4126-4136 (2008)
Tannemaat,M.R., J. Neurosci. 27 (52), 14260-14264 (2007)
Appleton,B.A., EMBO J. 26 (23), 4902-4912 (2007)
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