|Application ||WB, IHC-P, E|
|Calculated MW||27895 Da|
|Antigen Region||222-252 aa|
|Other Names||Amphiregulin, AR, Colorectum cell-derived growth factor, CRDGF, AREG, SDGF|
|Target/Specificity||This AREG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 222-252 amino acids from the C-terminal region of human AREG.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AREG Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.|
|Cellular Location||Membrane; Single-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
AREG is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This protein is associated with a psoriasis-like skin phenotype.
Shim,J.Y., J. Korean Med. Sci. 23 (5), 857-863 (2008)
Eckstein,N., J. Biol. Chem. 283 (2), 739-750 (2008)
Revillion,F., Ann. Oncol. 19 (1), 73-80 (2008)
Kimura,H., Nature 348 (6298), 257-260 (1990)
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