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WBP2 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - WBP2 Antibody (N-term) AP7786a
    Western blot analysis of anti-WBP2 Antibody (N-term) (Cat.#AP7786a) in A2058 cell line lysates (35ug/lane). WBP2 (arrow) was detected using the purified Pab.
    detail
  • IHC-P - WBP2 Antibody (N-term) AP7786a
    WBP2 Antibody (N-term) (Cat. #AP7786A)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of WBP2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, WB, E
Primary Accession Q969T9
Other Accession Q8R478, P97765
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 28087 Da
Antigen Region 19-47 aa
Additional Information
Gene ID 23558
Other Names WW domain-binding protein 2, WBP-2, WBP2
Target/Specificity This WBP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-47 amino acids from the N-terminal region of human WBP2.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsWBP2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name WBP2
Function Acts as a transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation (PubMed:16772533). In presence of estrogen, binds to ESR1-responsive promoters (PubMed:16772533). Required for YAP1 coactivation function on PGR activity (PubMed:16772533). Synergizes with WBP2 in enhancing PGR activity (PubMed:16772533). Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR (By similarity).
Cellular Location Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus when phosphorylated.
Tissue Location Ubiquitous.
Research Areas
Citations (0)
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Background

The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. WBP2 is a WW domain binding protein, which binds to the WW domain of Yes kinase-associated protein by its PY motifs. The function of this protein has not been determined.

References

Dhananjayan,S.C., Mol. Endocrinol. 20 (10), 2343-2354 (2006)
Nitsch,R., Biochem. J. 377 (PT 3), 553-560 (2004)
Jolliffe,C.N., Biochem. J. 351 PT 3, 557-565 (2000)

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$ 182.50
$ 70.00
Cat# AP7786a
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