|Application ||WB, E|
|Calculated MW||107235 Da|
|Antigen Region||451-480 aa|
|Other Names||Endoplasmic reticulum aminopeptidase 1, 3411-, ARTS-1, Adipocyte-derived leucine aminopeptidase, A-LAP, Aminopeptidase PILS, Puromycin-insensitive leucyl-specific aminopeptidase, PILS-AP, Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator, ERAP1, APPILS, ARTS1, KIAA0525|
|Target/Specificity||This ARTS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 451-480 amino acids from the Central region of human ARTS1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ARTS1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||APPILS, ARTS1, KIAA0525|
|Function||Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type II membrane protein|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Aminopeptidases play a role in the metabolism of several peptides that may be involved in blood pressure and the pathogenesis of essential hypertension. Adipocyte-derived leucine aminopeptidase (ALAP) is a member of the M1 family of zinc metallopeptidases.
Goto,Y., Biochem. J. 416 (1), 109-116 (2008)
Fruci,D., J. Cell. Physiol. 216 (3), 742-749 (2008)
Adamik,B., Biochem. Biophys. Res. Commun. 371 (3), 505-509 (2008)
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