|Application ||WB, IF, E|
|Other Accession||P97534, Q8HYX6, Q9Z2I2, P68107, P62943, P26883, P62942, P18203|
|Predicted||Bovine, Rabbit, Rat|
|Calculated MW||11783 Da|
|Antigen Region||1-30 aa|
|Other Names||Peptidyl-prolyl cis-trans isomerase FKBP1B, PPIase FKBP1B, 126 kDa FK506-binding protein, 126 kDa FKBP, FKBP-126, FK506-binding protein 1B, FKBP-1B, Immunophilin FKBP126, Rotamase, h-FKBP-12, FKBP1B, FKBP126, FKBP1L, FKBP9, OTK4|
|Target/Specificity||This FKBP1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human FKBP1B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FKBP1B Antibody (N-term E6) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||FKBP12.6, FKBP1L, FKBP9, OTK4|
|Function||Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.|
|Cellular Location||Cytoplasm. Sarcoplasmic reticulum|
|Tissue Location||Detected in heart muscle (at protein level). Isoform 1 and isoform 2 are ubiquitous with highest levels in brain and thymus.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
FKBP1B is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. The protein is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle.
Arakawa H., Nagase H.Biochem. Biophys. Res. Commun. 200:836-843(1994)
Lam E., Martin M.M., Timerman A.P.Biol. Chem. 270:26511-26522(1995)
Deivanayagam C.C., Carson M.Acta Crystallogr. D 56:266-271(2000)
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