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ALDH4A1 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

  • IHC-P - ALDH4A1 Antibody (Center) AP7875c
    Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with ALDH4A1 antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • WB - ALDH4A1 Antibody (Center) AP7875c
    Western blot analysis of anti-ALDH4A1 Antibody (Center) (Cat.#AP7875c) in HepG2 cell line lysates (35ug/lane). ALDH4A1(arrow) was detected using the purified Pab.
  • WB - ALDH4A1 Antibody (Center) AP7875c
    Western blot analysis of ALDH4A1 (arrow) using rabbit polyclonal ALDH4A1 Antibody (Center) (Cat.#AP7875c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the ALDH4A1 gene.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P30038
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 61719 Da
Antigen Region 288-314 aa
Additional Information
Gene ID 8659
Other Names Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial, P5C dehydrogenase, Aldehyde dehydrogenase family 4 member A1, L-glutamate gamma-semialdehyde dehydrogenase, ALDH4A1, ALDH4, P5CDH
Target/Specificity This ALDH4A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 288-314 amino acids from the Central region of human ALDH4A1.
Dilution IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsALDH4A1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ALDH4A1
Synonyms ALDH4, P5CDH
Function Irreversible conversion of delta-1-pyrroline-5- carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.
Cellular Location Mitochondrion matrix.
Tissue Location Highest expression is found in liver followed by skeletal muscle, kidney, heart, brain, placenta, lung and pancreas
Research Areas
Citations (0)

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ALDH4A1 belongs to the aldehyde dehydrogenase family of proteins. This enzyme is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associated with type II hyperprolinemia, an autosomal recessive disorder characterized by accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline.


Yoon,K.A., J. Hum. Genet. 49 (3), 134-140 (2004)
Geraghty,M.T., Hum. Mol. Genet. 7 (9), 1411-1415 (1998)

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$ 295.00
$ 99.00
Cat# AP7875c
(40 western blots)
Availability: In Stock
Bulk Size
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