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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CYP4F8 Antibody (C-term)   

CYP4F8 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CYP4F8 Antibody (C-term) AP7890b
    Western blot analysis of anti-CYP4F8 Antibody (C-term)(Cat.#AP7890b) in K562 cell line lysates (35ug/lane). CYP4F8(arrow) was detected using the purified Pab.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P98187
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 59995 Da
Antigen Region 473-503 aa
Additional Information
Gene ID 11283
Other Names Cytochrome P450 4F8, CYPIVF8, CYP4F8
Target/Specificity This CYP4F8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 473-503 amino acids from the C-terminal region of human CYP4F8.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCYP4F8 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CYP4F8
Function Hydroxylates arachidonic acid (20:4n-6) to (18R)- hydroxyarachidonate. Shows little activity against prostaglandin (PG) D2, PGE1, PGE2, PGF2alpha, and leukotriene B4. Catalyzes omega-2 and omega-3-hydroxylation of PGH1 and PGH2. Catalyzes epoxidation of 4,7,10,13,16,19-(Z)-docosahexaenoic acid (22:6n-3) and 7,10,13,16,19-(Z)-docosapentaenoic acid (22:5n-3) and omega-3- hydroxylation of 4,7,10,13,16-(Z)-docosapentaenoic acid (22:5n-6). Catalyzes hydroxylation of PGI2 and carbaprostacyclin.
Cellular Location Endoplasmic reticulum membrane; Single-pass membrane protein Microsome membrane
Tissue Location Expressed in the epithelium of seminal vesicles, in renal cortex, in adult and fetal liver, in epidermis, in corneal epithelium, in sweat glands, hair follicles, epithelial linings of the ampulla of vas deferens and of the stomach and small intestine, as well as in the transitional epithelium of the bladder and ureter (at protein level). In the epidermis, expressed from the basal cell to the granular cell layers. In the corneal epithelium, expressed in all cell layers. Also detected in prostate. Up-regulated in the epidermis of psoriatic lesions
Research Areas
Citations (0)

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CYP4F8 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and functions as a 19-hydroxylase of prostaglandins in seminal vesicles.


Bylund J., Finnstroem N., Biophys. Res. Commun. 261:169-174(1999)
Bylund J., Hidestrand M.,J. Biol. Chem. 275:21844-21849(2000)
Stark K., Toermae H.,Arch. Biochem. Biophys. 409:188-196(2003)
Stark K., Bylund J.,Prostaglandins Other Lipid Mediat. 75:47-64(2005)

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$ 295.00
$ 99.00
Cat# AP7890b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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