|Application ||WB, IHC-P, E|
|Calculated MW||57111 Da|
|Antigen Region||410-439 aa|
|Other Names||Cytochrome P450 26C1, 114--, CYP26C1|
|Target/Specificity||This CYP26C1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 410-439 amino acids from the C-terminal region of human CYP26C1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CYP26C1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA (preferred substrate).|
|Cellular Location||Membrane; Single-pass membrane protein|
|Tissue Location||Detected in most tissues at very low level.|
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Provided below are standard protocols that you may find useful for product applications.
CYP26C1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is involved in the catabolism of all-trans- and 9-cis-retinoic acid, and thus contributes to the regulation of retinoic acid levels in cells and tissues.
Rat,E., Birth Defects Res. Part A Clin. Mol. Teratol. 76 (6), 491-498 (2006)
Taimi,M., J. Biol. Chem. 279 (1), 77-85 (2004)
Nelson,D.R., Pharmacogenetics 14 (1), 1-18 (2004)
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