- CITATIONS: 1
|Application ||WB, E|
|Calculated MW||60102 Da|
|Antigen Region||88-120 aa|
|Other Names||Cholesterol side-chain cleavage enzyme, mitochondrial, CYPXIA1, Cholesterol desmolase, Cytochrome P450 11A1, Cytochrome P450(scc), CYP11A1, CYP11A|
|Target/Specificity||This CYP11A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-120 amino acids from the N-terminal region of human CYP11A1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CYP11A1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.|
|Cellular Location||Mitochondrion membrane.|
Provided below are standard protocols that you may find useful for product applications.
CYP11A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones.
Celhar,T., Cancer Genet. Cytogenet. 187 (1), 28-33 (2008)
Morales,A., Pancreas 37 (2), 165-169 (2008)
Shigematsu,K., Eur. J. Endocrinol. 158 (6), 867-878 (2008)
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