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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   LOK Antibody (C-term E707)   

LOK Antibody (C-term E707)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - LOK Antibody (C-term E707) AP7959b
    The anti-LOK Pab (Cat. #AP7959b) is used in Western blot to detect LOK in Jurkat cell lysate.
  • IHC-P - LOK Antibody (C-term E707) AP7959b
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O94804
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 112135 Da
Antigen Region 692-721 aa
Additional Information
Gene ID 6793
Other Names Serine/threonine-protein kinase 10, Lymphocyte-oriented kinase, STK10, LOK
Target/Specificity This LOK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 692-721 amino acids from the C-terminal region of human LOK.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLOK Antibody (C-term E707) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name STK10
Synonyms LOK
Function Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.
Cellular Location Cell membrane; Peripheral membrane protein
Tissue Location Highly expressed in rapidly proliferating tissues (spleen, placenta, and peripheral blood leukocytes). Also expressed in brain, heart, skeletal muscle, colon, thymus, kidney, liver, small intestine and lung.
Research Areas
Citations (0)

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This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway.


Kuramochi, S., et al., Immunogenetics 49(5):369-375 (1999).

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$ 295.00
$ 99.00
Cat# AP7959b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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