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MEK2 (MAP2K2) Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

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  • WB - MEK2 (MAP2K2) Antibody (Center) AP7961c
    All lanes : Anti-MEK2 (MAP2K2) Antibody (Center) at 1:1000 dilution Lane 1: Hela whole cell lysate Lane 2: MOLT-4 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 44 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • IF - MEK2 (MAP2K2) Antibody (Center) AP7961c
    Fluorescent image of U251 cell stained with MEK2 (MAP2K2) Antibody (Center)(Cat#AP7961c/SA110819AW).U251 cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with MEK2 primary antibody (1:25, 1 h at 37℃). For secondary antibody, Alexa Fluor® 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37℃).Cytoplasmic actin was counterstained with Alexa Fluor® 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37℃). MEK2 immunoreactivity is localized to Cytoplasm significantly.
  • WB - MEK2 (MAP2K2) Antibody (Center) AP7961c
    The anti-MAP2K2 Pab (Cat. #AP7961c) is used in Western blot to detect MAP2K2 in mouse liver tissue lysate.
  • WB - MEK2 (MAP2K2) Antibody (Center) AP7961c
    Western blot analysis of MAP2K2 (arrow) using MAP2K2 Antibody (Center) (Cat.#AP7961c).293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MAP2K2 gene (Lane 2) (Origene Technologies).
  • IHC-P - MEK2 (MAP2K2) Antibody (Center) AP7961c
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
  • WB - MEK2 (MAP2K2) Antibody (Center) AP7961c
    MAP2K2 Antibody (A278) (Cat. #AP7961c) western blot analysis in U937 cell line lysates (35ug/lane).This demonstrates the MAP2K2 antibody detected the MAP2K2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P36507
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 44424 Da
Antigen Region 262-292 aa
Additional Information
Gene ID 5605
Other Names Dual specificity mitogen-activated protein kinase kinase 2, MAP kinase kinase 2, MAPKK 2, ERK activator kinase 2, MAPK/ERK kinase 2, MEK 2, MAP2K2, MEK2, MKK2, PRKMK2
Target/Specificity This MEK2 (MAP2K2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 262-292 amino acids from the Central region of human MEK2 (MAP2K2).
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMEK2 (MAP2K2) Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAP2K2
Synonyms MEK2, MKK2, PRKMK2
Function Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity).
Research Areas
Citations (0)

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MAP2K2 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax.


Burroughs, K.D., et al., Mol. Cancer Res. 1(4):312-322 (2003).
Tran, H., et al., Mol. Cell. Biol. 23(20):7177-7188 (2003).
Li, S.P., et al., Cancer Res. 63(13):3473-3477 (2003).
Li, Y., et al., J. Biol. Chem. 278(16):13663-13671 (2003).
Liu, X., et al., J. Biol. Chem. 277(42):39312-39319 (2002).

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$ 295.00
$ 99.00
Cat# AP7961c
(40 western blots)
Availability: In Stock
Bulk Size
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