|Application ||WB, IHC-P, E|
|Calculated MW||113557 Da|
|Antigen Region||23-53 aa|
|Other Names||Tolloid-like protein 2, 3424-, TLL2, KIAA0932|
|Target/Specificity||This TLL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 23-53 amino acids from the N-terminal region of human TLL2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TLL2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protease which specifically processes pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.|
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Provided below are standard protocols that you may find useful for product applications.
TLL2 is an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. Unlike other family members, a similar protein in mice does not cleave procollagen C-propeptides or chordin.
Scott,I.C., Dev. Biol. 213 (2), 283-300 (1999)
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