|Application ||WB, IHC-P, E|
|Other Accession||G3V7X8, Q811W2|
|Calculated MW||57513 Da|
|Antigen Region||398-430 aa|
|Other Names||Cytochrome P450 26B1, 114--, Cytochrome P450 26A2, Cytochrome P450 retinoic acid-inactivating 2, Cytochrome P450RAI-2, Retinoic acid-metabolizing cytochrome, CYP26B1, CYP26A2, P450RAI2|
|Target/Specificity||This CYP26B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 398-430 amino acids from the C-terminal region of human CYP26B1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CYP26B1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH- RA. Esential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints.|
|Cellular Location||Endoplasmic reticulum membrane; Peripheral membrane protein Microsome membrane; Peripheral membrane protein|
|Tissue Location||Highly expressed in brain, particularly in the cerebellum and pons.|
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Provided below are standard protocols that you may find useful for product applications.
CYP26B1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and the synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene is involved in the specific inactivation of all-trans-retinoic acid to hydroxylated forms, such as 4-oxo-, 4-OH-, and 18-OH-all-trans-retinoic acid.
Bowles,J., Science 312 (5773), 596-600 (2006)
Nelson,D.R., Pharmacogenetics 14 (1), 1-18 (2004)
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