|Application ||WB, IF, FC, E|
|Calculated MW||57670 Da|
|Antigen Region||242-270 aa|
|Other Names||Cytochrome P450 3A43, CYP3A43|
|Target/Specificity||This CYP3A43 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 242-270 amino acids from the Central region of human CYP3A43.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CYP3A43 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Exhibits low testosterone 6-beta-hydroxylase activity.|
|Cellular Location||Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein|
|Tissue Location||Highest expression level in prostate. Also expressed in liver, kidney, pancreas, fetal liver and fetal skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
CYP3A43 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein has a low level of testosterone hydroxylase activity. Although it bears homology to some drug-metabolizing cytochrome P450s, the protein unknown whether the enzyme is also involved in xenobiotic metabolism.
Domanski T.L., Finta C.Mol. Pharmacol. 59:386-392(2001)
Westlind A., Malmebo S.Biochem. Biophys. Res. Commun. 281:1349-1355(2001)
Cauffiez C., Lo-Guidice J.-M.Hum. Mutat. 23:101-101(2004)
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