- CITATIONS: 6
|Application ||WB, IHC-P, E|
|Other Accession||Q63285, P97343|
|Calculated MW||46546 Da|
|Antigen Region||1-30 aa|
|Other Names||Serine/threonine-protein kinase Kist, Kinase interacting with stathmin, PAM COOH-terminal interactor protein 2, P-CIP2, U2AF homology motif kinase 1, UHMK1, KIS, KIST|
|Target/Specificity||This KIST (KIS) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human KIST (KIS).|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KIST (KIS) Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity).|
|Tissue Location||Widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral blood leukocytes|
Provided below are standard protocols that you may find useful for product applications.
Upon serum stimulation, KIS, a member of the Ser/Thr protein kinase family, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. This protein, which contains 1 RRM (RNA recognition motif)domain, may be involved in trafficking and/or processing of RNA. KIS is widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral blood leukocytes.
Bieche, I., et al., Brain Res. Mol. Brain Res. 114(1):55-64 (2003).
Boehm, M., et al., EMBO J. 21(13):3390-3401 (2002).
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