|Application ||WB, E|
|Calculated MW||74192 Da|
|Antigen Region||480-510 aa|
|Other Names||Serine/threonine-protein kinase Nek11, Never in mitosis A-related kinase 11, NimA-related protein kinase 11, NEK11 (HGNC:18593)|
|Target/Specificity||This NEK11L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 480-510 amino acids from the C-terminal region of human NEK11L.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NEK11L Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation.|
|Cellular Location||Nucleus. Nucleus, nucleolus. Note=Nuclear during interphase but moves to the polar microtubules during prometaphase and metaphase. Accumulates in the nucleolus in G1/S- arrested cells|
|Tissue Location||Poorly expressed in cerebellum, trachea, lung, appendix, and uterus.|
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Provided below are standard protocols that you may find useful for product applications.
NEK11 belongs to the NIMA family of kinases, which are involved in DNA replication and genotoxic stress responses (Noguchi et al., 2002 [PubMed 12154088]).[supplied by OMIM]
Blume-Jensen P, et al. Nature 2001. 411: 355.
Cantrell D, J. Cell Sci. 2001. 114: 1439.
Jhiang S Oncogene 2000. 19: 5590.
Manning G, et al. Science 2002. 298: 1912.
Moller, D, et al. Am. J. Physiol. 1994. 266: C351-C359.
Robertson, S. et al. Trends Genet. 2000. 16: 368.
Robinson D, et al. Oncogene 2000. 19: 5548.
Van der Ven, P, et al. Hum. Molec. Genet. 1993. 2: 1889.
Vanhaesebroeck, B, et al. Biochem. J. 2000. 346: 561.
Van Weering D, et al. Recent Results Cancer Res. 1998. 154: 271.
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