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AK5 Antibody (N-term)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP8131a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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AK5 Antibody (N-term) - Product info | |
| Application | WB, IHC
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| Primary Accession | Q9Y6K8 |
| Reactivity | Human, Mouse |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 63333 Da |
AK5 Antibody (N-term) - Additional info | |
| Gene ID 26289 | |
| Other Names AK5; Adenylate kinase isoenzyme 5; ATP-AMP transphosphorylase 5 | |
| Target/Specificity This AK5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46~76 amino acids from the N-terminal region of human AK5. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:50~100 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions AK5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
AK5 Antibody (N-term) - Protein Information | |
| Name AK5 | |
| Function Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP | |
| Cellular Location Cytoplasm. | |
| Tissue Location Brain specific. | |
AK5 Antibody (N-term) - Related products
AP8131a: AK5 Antibody (N-term)
AP8131b: AK5 Antibody (C-term)
LY10007a: AK5 Over-expression Lysate
AK5 Antibody (N-term) - Application data
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The anti-AK5 Pab (Cat. #AP8131a) is used in Western blot to detect AK5 in mouse liver tissue lysate.
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Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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Formalin-fixed and paraffin-embedded human brain tissue reacted with AK5 Antibody (N-term) (Cat.#AP8131a), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
AK5 Antibody (N-term) - Research Areas
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BACKGROUND
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK).
REFERENCES
Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002). Van Rompay, A.R., et al., Eur. J. Biochem. 261(2):509-517 (1999).
