ITPKB Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, IHC-P, WB, E |
---|---|
Primary Accession | P27987 |
Other Accession | NP_002212 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 102376 Da |
Antigen Region | 23-54 aa |
Gene ID | 3707 |
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Other Names | Inositol-trisphosphate 3-kinase B, Inositol 1, 5-trisphosphate 3-kinase B, IP3 3-kinase B, IP3K B, InsP 3-kinase B, ITPKB |
Target/Specificity | This ITPKB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 23-54 amino acids from the N-terminal region of human ITPKB. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ITPKB Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ITPKB (HGNC:6179) |
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Function | Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5- trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. |
Cellular Location | Cytoplasm, cytoskeleton. Cytoplasm Endoplasmic reticulum |
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Provided below are standard protocols that you may find useful for product applications.
Background
ITPKB regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity.
References
Dewaste, V., et al., Biochem. Biophys. Res. Commun. 291(2):400-405 (2002).
Woodring, P.J., et al., J. Biol. Chem. 272(48):30447-30454 (1997).
Erneux, C., et al., Genomics 14(2):546-547 (1992).
Takazawa, K., et al., Biochem. J. 272(1):107-112 (1990).
Takazawa, K., et al., Biochem. J. 278 (PT 3), 883-886 (1991) (): ().
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