|Application ||WB, IHC-P, FC, E|
|Calculated MW||102376 Da|
|Antigen Region||23-54 aa|
|Other Names||Inositol-trisphosphate 3-kinase B, Inositol 1, 5-trisphosphate 3-kinase B, IP3 3-kinase B, IP3K B, InsP 3-kinase B, ITPKB|
|Target/Specificity||This ITPKB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 23-54 amino acids from the N-terminal region of human ITPKB.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ITPKB Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
ITPKB regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity.
Dewaste, V., et al., Biochem. Biophys. Res. Commun. 291(2):400-405 (2002).
Woodring, P.J., et al., J. Biol. Chem. 272(48):30447-30454 (1997).
Erneux, C., et al., Genomics 14(2):546-547 (1992).
Takazawa, K., et al., Biochem. J. 272(1):107-112 (1990).
Takazawa, K., et al., Biochem. J. 278 (PT 3), 883-886 (1991) (): ().
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