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MVP Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - MVP Antibody (N-term) AP8169a
    Western blot analysis of MVK (arrow) using rabbit polyclonal MVK Antibody (N-term) (Cat. #AP8169a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MVK gene (Lane 2).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q03426
Other Accession NP_000422
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 42451 Da
Antigen Region 17-47 aa
Additional Information
Gene ID 4598
Other Names Mevalonate kinase, MK, MVK
Target/Specificity This MVK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-47 amino acids from the N-terminal region of human MVK.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMVP Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MVK (HGNC:7530)
Function Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis (PubMed:9325256, PubMed:18302342, PubMed:9392419, PubMed:11278915).
Cellular Location Cytoplasm. Peroxisome {ECO:0000250|UniProtKB:P17256}
Research Areas
Citations (0)
citation

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Background

MVK encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of MVK results in mevalonic aciduria.

References

Stojanov, S., et al., Arthritis Rheum. 50(6):1951-1958 (2004).
Nair, A.K., et al., J. Biol. Chem. 279(15):14937-14944 (2004).
Simon, A., et al., Neurology 62(6):994-997 (2004).
Houten, S.M., et al., J. Biol. Chem. 278(8):5736-5743 (2003).
Houten, S.M., et al., Eur. J. Hum. Genet. 11(2):196-200 (2003).

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$ 182.50
$ 70.00
Cat# AP8169a
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