|Application ||WB, E|
|Calculated MW||42451 Da|
|Antigen Region||17-47 aa|
|Other Names||Mevalonate kinase, MK, MVK|
|Target/Specificity||This MVK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-47 amino acids from the N-terminal region of human MVK.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MVP Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be a regulatory site in cholesterol biosynthetic pathway.|
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Provided below are standard protocols that you may find useful for product applications.
MVK encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of MVK results in mevalonic aciduria.
Stojanov, S., et al., Arthritis Rheum. 50(6):1951-1958 (2004).
Nair, A.K., et al., J. Biol. Chem. 279(15):14937-14944 (2004).
Simon, A., et al., Neurology 62(6):994-997 (2004).
Houten, S.M., et al., J. Biol. Chem. 278(8):5736-5743 (2003).
Houten, S.M., et al., Eur. J. Hum. Genet. 11(2):196-200 (2003).
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