|Application ||WB, IHC-P, E|
|Calculated MW||68020 Da|
|Antigen Region||477-505 aa|
|Other Names||Tyrosine-protein phosphatase non-receptor type 9, Protein-tyrosine phosphatase MEG2, PTPase MEG2, PTPN9|
|Target/Specificity||This MEG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 477-505 amino acids from the C-terminal region of human MEG2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MEG2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus.|
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Provided below are standard protocols that you may find useful for product applications.
MEG2 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant similarity with yeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required for protein secretion through the Golgi complex in yeast. This PTP was found to be activated by polyphosphoinositide, and is thought to be involved in signaling events regulating phagocytosis.
Kruger, J.M., et al., J. Biol. Chem. 277(4):2620-2628 (2002).
Qi, Y., et al., J. Cell. Biochem. 86(1):79-89 (2002).
Gu, M., et al., Proc. Natl. Acad. Sci. U.S.A. 89(7):2980-2984 (1992).
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