|Application ||WB, E|
|Calculated MW||111271 Da|
|Antigen Region||94-125 aa|
|Other Names||Receptor-type tyrosine-protein phosphatase N2, R-PTP-N2, Islet cell autoantigen-related protein, IAR, ICAAR, Phogrin, PTPRN2, KIAA0387|
|Target/Specificity||This PTPIA2 beta antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 94-125 amino acids from the N-terminal region of human PTPIA2 beta.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PTPIA2 beta Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Implicated in development of nervous system and pancreatic endocrine cells.|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type I membrane protein|
|Tissue Location||Highest levels in brain and pancreas. Lower levels in trachea, prostate, stomach and spinal chord|
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Provided below are standard protocols that you may find useful for product applications.
PTPIA2beta is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus.
Schmidli, R.S., et al., Autoimmunity 28(1):15-23 (1998).
Li, Q., et al., Proc. Assoc. Am. Physicians 109(4):429-439 (1997).
Cui, L., et al., J. Biol. Chem. 271(40):24817-24823 (1996).
Kawasaki, E., et al., Biochem. Biophys. Res. Commun. 227(2):440-447 (1996).
Smith, P.D., et al., Biochem. Biophys. Res. Commun. 229(2):402-411 (1996).
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