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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PTPIA2 beta Antibody (N-term)   

PTPIA2 beta Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PTPIA2 beta Antibody (N-term) AP8427a
    The anti-PTPIA2 beta N-term Pab (Cat. #AP8427a) is used in Western blot to detect PTPIA2 beta in C6 cell lysate.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92932
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 111271 Da
Antigen Region 94-125 aa
Additional Information
Gene ID 5799
Other Names Receptor-type tyrosine-protein phosphatase N2, R-PTP-N2, Islet cell autoantigen-related protein, IAR, ICAAR, Phogrin, PTPRN2, KIAA0387
Target/Specificity This PTPIA2 beta antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 94-125 amino acids from the N-terminal region of human PTPIA2 beta.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPTPIA2 beta Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KIAA0387
Function Implicated in development of nervous system and pancreatic endocrine cells.
Cellular Location Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type I membrane protein
Tissue Location Highest levels in brain and pancreas. Lower levels in trachea, prostate, stomach and spinal chord
Research Areas
Citations (0)

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PTPIA2beta is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus.


Schmidli, R.S., et al., Autoimmunity 28(1):15-23 (1998).
Li, Q., et al., Proc. Assoc. Am. Physicians 109(4):429-439 (1997).
Cui, L., et al., J. Biol. Chem. 271(40):24817-24823 (1996).
Kawasaki, E., et al., Biochem. Biophys. Res. Commun. 227(2):440-447 (1996).
Smith, P.D., et al., Biochem. Biophys. Res. Commun. 229(2):402-411 (1996).

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Cat# AP8427a
(40 western blots)
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