|Application ||WB, IHC-P, E|
|Other Accession||Q91Z46, NP_001938|
|Calculated MW||44957 Da|
|Antigen Region||96-127 aa|
|Other Names||Dual specificity protein phosphatase 7, Dual specificity protein phosphatase PYST2, DUSP7, PYST2|
|Target/Specificity||This DUSP7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-127 amino acids from the N-terminal region of human DUSP7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DUSP7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulates the activity of the MAP kinase family in response to changes in the cellular environment. PYST2-S may act as a negative regulator of PYST2-L although it is unclear whether this is by competing for transcription, translation or activation factors.|
|Tissue Location||Expressed at significantly higher levels in malignant hematopoietic cells than in corresponding non-malignant cells.|
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Provided below are standard protocols that you may find useful for product applications.
DUSP7 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP)kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.
Immunol. Lett. 92 (1-2), 149-156 (2004)
Oncogene 22 (48), 7649-7660 (2003)
Meth. Enzymol. 366, 103-113 (2003)
J. Cell. Sci. 111 (PT 22), 3389-3399 (1998)
EMBO J. 15 (14), 3621-3632 (1996)
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