|Application ||WB, IHC-P, E|
|Calculated MW||65827 Da|
|Antigen Region||456-487 aa|
|Other Names||Dual specificity protein phosphatase 8, Dual specificity protein phosphatase hVH-5, DUSP8, C11orf81, VH5|
|Target/Specificity||This DUSP8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 456-487 amino acids from the C-terminal region of human DUSP8.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DUSP8 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This protein shows both activity toward tyrosine-protein phosphate as well as with serine/threonine-protein phosphate.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Abundant in brain, heart and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
DUSP8 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP8 inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin.
Berger, I.R., et al., Cancer Genet. Cytogenet. 159(2):155-159 (2005).
Hink, R.L., et al., Genomics 8(3):305-312 (2003).
Nesbit, M.A., et al., Genomics 42(2):284-294 (1997).
Martell, K.J., et al., J. Neurochem. 65(4):1823-1833 (1995).
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