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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   DUSP1 Antibody (N-term)   

DUSP1 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - DUSP1 Antibody (N-term) AP8470a
    The anti-DUSP1 Pab (Cat. #AP8470a) is used in Western blot to detect DUSP1 in 293 cell lysate.
  • IF - DUSP1 Antibody (N-term) AP8470a
    Confocal immunofluorescent analysis of DUSP1 Antibody (N-term)(Cat#AP8470a) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P28562
Other Accession P28563
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 39298 Da
Antigen Region 46-76 aa
Additional Information
Gene ID 1843
Other Names Dual specificity protein phosphatase 1, Dual specificity protein phosphatase hVH1, Mitogen-activated protein kinase phosphatase 1, MAP kinase phosphatase 1, MKP-1, Protein-tyrosine phosphatase CL100, DUSP1, CL100, MKP1, PTPN10, VH1
Target/Specificity This DUSP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-76 amino acids from the N-terminal region of human DUSP1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDUSP1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DUSP1
Synonyms CL100, MKP1, PTPN10, VH1
Function Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.
Cellular Location Nucleus.
Tissue Location Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney
Research Areas
Citations (0)

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The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.


Wu,W., et al., J. Biol. Chem. 280 (6), 4117-4124 (2005).
Small,G.W., et al., Mol. Pharmacol. 66 (6), 1478-1490 (2004).
Chandrasekharan,U.M., et al., J. Biol. Chem. 279 (45), 46678-46685 (2004).
Mizuno,R., et al., J. Urol. 172 (2), 723-727 (2004).
Vicent,S., et al., Clin. Cancer Res. 10 (11), 3639-3649 (2004).

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Cat# AP8470a
(40 western blots)
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