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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   LTA Antibody (Center)   

LTA Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - LTA Antibody (Center) AP8509c
    Western blot analysis of LTA Antibody (Center) (Cat. #AP8509c) in MDA-MB231 cell line lysates (35ug/lane). LTA (arrow) was detected using the purified Pab.
  • IHC-P - LTA Antibody (Center) AP8509c
    Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with LTA Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - LTA Antibody (Center) AP8509c
    Flow cytometric analysis of HepG2 cells using LTA Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P01374
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 22297 Da
Antigen Region 46-72 aa
Additional Information
Gene ID 4049
Other Names Lymphotoxin-alpha, LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA, TNFB, TNFSF1
Target/Specificity This LTA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-72 amino acids from the Central region of human LTA.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLTA Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LTA
Synonyms TNFB, TNFSF1
Function Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.
Cellular Location Secreted. Membrane. Note=The homotrimer is secreted. The heterotrimer is membrane-associated
Research Areas
Citations (0)

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LTA, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis.


Buonaguro,L.,, J. Virol. 66 (12), 7159-7167 (1992)
Fukushima,K.,, Arch. Biochem. Biophys. 304 (1), 144-153 (1993)

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$ 295.00
$ 99.00
Cat# AP8509c
(40 western blots)
Availability: In Stock
Bulk Size
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