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LTA Antibody (Center)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP8509c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
LTA Antibody (Center) - Product info | |
| Application | WB, IHC, FC
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| Primary Accession | P01374 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 22297 Da |
LTA Antibody (Center) - Additional info | |
| Gene ID 4049 | |
| Other Names LTA; TNFB; TNFSF1; Lymphotoxin-alpha; TNF-beta; Tumor necrosis factor ligand superfamily member 1 | |
| Target/Specificity This LTA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52~81 amino acids from the Center region of human LTA. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:50~100 FC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions LTA Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
LTA Antibody (Center) - Protein Information | |
| Name LTA | |
| Synonyms TNFB, TNFSF1 | |
| Function Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo | |
| Cellular Location Secreted. Membrane. Note=The homotrimer is secreted. The heterotrimer is membrane-associated | |
LTA Antibody (Center) - Related products
AP8509c: LTA Antibody (Center)
LY11757a: LTA Over-expression Lysate
LTA Antibody (Center) - Application data
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Western blot analysis of LTA Antibody (Center) (Cat. #AP8509c) in MDA-MB231 cell line lysates (35ug/lane). LTA (arrow) was detected using the purified Pab.
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Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with LTA Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Flow cytometric analysis of HepG2 cells using LTA Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
LTA Antibody (Center) - Research Areas
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BACKGROUND
LTA, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis.
REFERENCES
Buonaguro,L., et.al., J. Virol. 66 (12), 7159-7167 (1992) Fukushima,K., et.al., Arch. Biochem. Biophys. 304 (1), 144-153 (1993)
