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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ABCC5 Antibody (Center)   

ABCC5 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - ABCC5 Antibody (Center) AP8578c
    Western blot analysis of ABCC5 Antibody (Center) (Cat. #AP8578c) in 293 cell line lysates (35ug/lane). ABCC5 (arrow) was detected using the purified Pab.(2ug/ml)
  • IHC-P - ABCC5 Antibody (Center) AP8578c
    Formalin-fixed and paraffin-embedded human brain tissue with ABCC5 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - ABCC5 Antibody (Center) AP8578c
    Flow cytometric analysis of 293 cells using ABCC5 Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O15440
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 160660 Da
Antigen Region 625-652 aa
Additional Information
Gene ID 10057
Other Names Multidrug resistance-associated protein 5, ATP-binding cassette sub-family C member 5, Multi-specific organic anion transporter C, MOAT-C, SMRP, pABC11, ABCC5, MRP5
Target/Specificity This ABCC5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 625-652 amino acids from the Central region of human ABCC5.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsABCC5 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ABCC5
Synonyms MRP5
Function Acts as a multispecific organic anion pump which can transport nucleotide analogs.
Cellular Location Membrane; Multi-pass membrane protein.
Tissue Location All isoforms are equally expressed in retina.
Research Areas
Citations (0)

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ABCC5 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs,6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients.


Olsen,J.V.,, Cell 127 (3), 635-648 (2006)

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Cat# AP8578c
(40 western blots)
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