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ABCC5 Antibody (Center)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP8578c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP8578c-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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ABCC5 Antibody (Center) - Product info | |
| Application | WB, IHC, FC
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| Primary Accession | O15440 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 160660 Da |
ABCC5 Antibody (Center) - Additional info | |
| Gene ID 10057 | |
| Other Names ABCC5; MRP5; Multidrug resistance-associated protein 5; ATP-binding cassette sub-family C member 5; Multi-specific organic anion transporter C; SMRP; pABC11 | |
| Target/Specificity This ABCC5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 631~661 amino acids from the Center region of human ABCC5. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:50~100 FC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ABCC5 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ABCC5 Antibody (Center) - Protein Information | |
| Name ABCC5 | |
| Synonyms MRP5 | |
| Function Acts as a multispecific organic anion pump which can transport nucleotide analogs | |
| Cellular Location Membrane; Multi-pass membrane protein. | |
| Tissue Location All isoforms are equally expressed in retina. | |
ABCC5 Antibody (Center) - Related products
AP8578c: ABCC5 Antibody (Center)
RI10023: ABCC5 predesign siRNA
ABCC5 Antibody (Center) - Application data
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Western blot analysis of ABCC5 Antibody (Center) (Cat. #AP8578c) in 293 cell line lysates (35ug/lane). ABCC5 (arrow) was detected using the purified Pab.(2ug/ml)
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Formalin-fixed and paraffin-embedded human brain tissue with ABCC5 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Flow cytometric analysis of 293 cells using ABCC5 Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
ABCC5 Antibody (Center) - Research Areas
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BACKGROUND
ABCC5 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs,6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients.
REFERENCES
Olsen,J.V., et.al., Cell 127 (3), 635-648 (2006)
