|Application ||WB, IHC-P, FC, E|
|Calculated MW||99399 Da|
|Antigen Region||262-288 aa|
|Other Names||Phosphatidate phosphatase LPIN2, Lipin-2, LPIN2, KIAA0249|
|Target/Specificity||This LPIN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 262-288 amino acids from the Central region of human LPIN2.|
|Precautions||LPIN2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism (By similarity).|
|Cellular Location||Nucleus. Cytoplasm, cytosol. Endoplasmic reticulum membrane Note=Translocates to endoplasmic reticulum membrane with increasing levels of oleate.|
|Tissue Location||Expressed in liver, lung, kidney, placenta, spleen, thymus, lymph node, prostate, testes, small intestine, and colon.|
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Provided below are standard protocols that you may find useful for product applications.
Defects in LPIN2 are the cause of Majeed syndrome. Majeed syndrome is an autosomal recessive disorder combining features of chronic recurrent multifocal osteomyelitis, congenital dyserythropoietic anemia and inflammatory dermatosis.
Olsen,J.V., et.al., Cell 127 (3), 635-648 (2006)
Ferguson,P.J., et.al., J. Med. Genet. 42 (7), 551-557 (2005)
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