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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   LPIN2 Antibody (Center)   

LPIN2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - LPIN2 Antibody (Center) AP8583c
    Western blot analysis of LPIN2 Antibody (Center) (Cat. #AP8583c) in K562 cell line lysates (35ug/lane).LPIN2 (arrow) was detected using the purified Pab.(2ug/ml)
  • IHC-P - LPIN2 Antibody (Center) AP8583c
    Formalin-fixed and paraffin-embedded human hepatocarcinoma with LPIN2 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - LPIN2 Antibody (Center) AP8583c
    Flow cytometric analysis of K562 cells using LPIN2 Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92539
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 99399 Da
Antigen Region 262-288 aa
Additional Information
Gene ID 9663
Other Names Phosphatidate phosphatase LPIN2, Lipin-2, LPIN2, KIAA0249
Target/Specificity This LPIN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 262-288 amino acids from the Central region of human LPIN2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLPIN2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LPIN2
Synonyms KIAA0249
Function Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism (By similarity).
Cellular Location Nucleus. Cytoplasm, cytosol. Endoplasmic reticulum membrane Note=Translocates to endoplasmic reticulum membrane with increasing levels of oleate.
Tissue Location Expressed in liver, lung, kidney, placenta, spleen, thymus, lymph node, prostate, testes, small intestine, and colon.
Research Areas
Citations (0)

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Defects in LPIN2 are the cause of Majeed syndrome. Majeed syndrome is an autosomal recessive disorder combining features of chronic recurrent multifocal osteomyelitis, congenital dyserythropoietic anemia and inflammatory dermatosis.


Olsen,J.V.,, Cell 127 (3), 635-648 (2006)
Ferguson,P.J.,, J. Med. Genet. 42 (7), 551-557 (2005)

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Cat# AP8583c
(40 western blots)
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