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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ADIPOR1 Antibody (C-term)   

ADIPOR1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - ADIPOR1 Antibody (C-term) AP8634B
    Anti-ADIPOR1 Antibody (C-term) at 1:1000 dilution + MCF-7 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 43 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - ADIPOR1 Antibody (C-term) AP8634B
    Western blot analysis of ADIPOR1 Antibody (C-term) (Cat. #AP8634b) in Y79 cell line lysates (35ug/lane). ADIPOR1 (arrow) was detected using the purified Pab.
  • IHC-P - ADIPOR1 Antibody (C-term) AP8634B
    Formalin-fixed and paraffin-embedded human hepatocarcinoma with ADIPOR1 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - ADIPOR1 Antibody (C-term) AP8634B
    Flow cytometric analysis of widr cells using ADIPOR1 Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, FC, E
Primary Accession Q96A54
Other Accession Q91VH1
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 42616 Da
Antigen Region 305-331 aa
Additional Information
Gene ID 51094
Other Names Adiponectin receptor protein 1, Progestin and adipoQ receptor family member I, ADIPOR1, PAQR1, TESBP1A
Target/Specificity This ADIPOR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 305-331 amino acids from the C-terminal region of human ADIPOR1.
Dilution WB~~1:1000
IHC-P~~1:10~50
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsADIPOR1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ADIPOR1
Synonyms PAQR1 {ECO:0000303|PubMed:16044242}, TES
Function Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:25855295, PubMed:12802337). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein Note=Localized to the cell membrane and intracellular organelles
Tissue Location Widely expressed (PubMed:16044242). Highly expressed in heart and skeletal muscle (PubMed:12802337) Expressed at intermediate level in brain, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes (PubMed:12802337) Weakly expressed in colon, thymus and small intestine (PubMed:12802337).
Research Areas
Citations (0)

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Background

The adiponectin receptors, ADIPOR1 and ADIPOR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-alpha ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.

References

Civitarese,A.E., et.al., Diabetologia 47 (5), 816-820 (2004)
Wang,H., et.al., Diabetes 53 (8), 2132-2136 (2004)

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$ 295.00
$ 99.00
Cat# AP8634B
Size:
Quantity:
(40 western blots)
Availability: In Stock
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