|Application ||WB, IHC-P, FC, E|
|Calculated MW||42616 Da|
|Antigen Region||305-331 aa|
|Other Names||Adiponectin receptor protein 1, Progestin and adipoQ receptor family member I, ADIPOR1, PAQR1, TESBP1A|
|Target/Specificity||This ADIPOR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 305-331 amino acids from the C-terminal region of human ADIPOR1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ADIPOR1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:25855295, PubMed:12802337). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein Note=Localized to the cell membrane and intracellular organelles|
|Tissue Location||Widely expressed (PubMed:16044242). Highly expressed in heart and skeletal muscle (PubMed:12802337) Expressed at intermediate level in brain, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes (PubMed:12802337) Weakly expressed in colon, thymus and small intestine (PubMed:12802337).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The adiponectin receptors, ADIPOR1 and ADIPOR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-alpha ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.
Civitarese,A.E., et.al., Diabetologia 47 (5), 816-820 (2004)
Wang,H., et.al., Diabetes 53 (8), 2132-2136 (2004)
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