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>   home   >   Products   >   Primary Antibodies   >   Microbiology   >   Beclin1-BH3 Domain Antibody   

Beclin1-BH3 Domain Antibody

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Beclin1-BH3 Domain Antibody AP8653a
    Western blot analysis of Beclin1-BH3 Domain Antibody (Cat. #AP8653a) in mouse stomach tissue lysates (35ug/lane). BECN1 (arrow) was detected using the purified Pab.
  • IHC-P - Beclin1-BH3 Domain Antibody AP8653a
    Beclin1-BH3 Domain Antibody (Cat. #AP8653a) IHC analysis in formalin fixed and paraffin embedded mouse brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the Beclin1-BH3 Domain Antibody for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - Beclin1-BH3 Domain Antibody AP8653a
    Beclin1-BH3 Domain Antibody (Cat. #AP8653a) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14457
Other Accession Q6GP52, Q91XJ1, Q4A1L5, O88597, Q5ZKS6, Q4A1L4
Reactivity Human, Mouse
Predicted Bovine, Chicken, Pig, Rat, Xenopus
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 51896 Da
Antigen Region 95-132 aa
Additional Information
Gene ID 8678
Other Names Beclin-1, Coiled-coil myosin-like BCL2-interacting protein, Protein GT197, BECN1, GT197
Target/Specificity This Beclin1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-132 amino acids from human Beclin1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBeclin1-BH3 Domain Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BECN1
Synonyms GT197
Function Plays a central role in autophagy (PubMed:23184933). Required for the abcission step in cytokinesis (PubMed:20208530). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense.
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:O88597}. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein. Note=Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity) {ECO:0000250|UniProtKB:O88597, ECO:0000269|PubMed:19050071}
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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Beclin1-BH3 plays a central role in autophagy (By similarity). It may play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.


Won,K.Y.,, Hum. Pathol. 41 (1), 107-112 (2010) Oberstein,A.,, J. Biol. Chem. 282 (17), 13123-13132 (2007)

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Cat# AP8653a
(40 western blots)
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