|Application ||WB, FC, E|
|Calculated MW||89282 Da|
|Antigen Region||119-146 aa|
|Other Names||B-cell scaffold protein with ankyrin repeats, BANK1|
|Target/Specificity||This BANK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 119-146 amino acids from the Central region of human BANK1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Precautions||BANK1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2.|
|Tissue Location||Expressed in B-cell but not T-cell or myeloid cell lines. Highest expression in CD19(+) B-cells, with very low expression in other cell populations|
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Provided below are standard protocols that you may find useful for product applications.
BANK1 is a B-cell-specific scaffold protein and LYN (MIM 165120) tyrosine kinase substrate that promotes tyrosine phosphorylation of inositol 1,4,5-trisphosphate receptors.
Orozco,G., et.al., Arthritis Rheum. 60 (2), 372-379 (2009)
Guo,L., et.al., Genes Immun. 10 (5), 531-538 (2009)
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