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SNAI Antibody

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SNAI Antibody AP8696a
    Western blot analysis of SNAI Antibody (Cat. #AP8696a) in 293 cell line lysates (35ug/lane). SNAI (arrow) was detected using the purified Pab.
  • IHC-P - SNAI Antibody AP8696a
    Formalin-fixed and paraffin-embedded human testis tissue reacted with SNAI Antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - SNAI Antibody AP8696a
    SNAI Antibody (Cat. #AP8696a) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95863
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 29083 Da
Additional Information
Gene ID 6615
Other Names Zinc finger protein SNAI1, Protein snail homolog 1, Protein sna, SNAI1, SNAH
Target/Specificity This SNAI antibody is generated from rabbits immunized with SNAI recombinant protein.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSNAI Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SNAI1
Synonyms SNAH
Function Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up- regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.
Cellular Location Nucleus. Cytoplasm. Note=Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs
Tissue Location Expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal and epithelial cell lines.
Research Areas
Citations (0)

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The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo.


Beausoleil,S.A.,, Proc. Natl. Acad. Sci. U.S.A. 101 (33), 12130-12135 (2004)

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Cat# AP8696a
(40 western blots)
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