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DERL2 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - DERL2 Antibody (C-term) AP8707b
    Western blot analysis of DERL2 Antibody (C-term) (Cat. #AP8707b) in MDA-MB231 cell line lysates (35ug/lane). DERL2 (arrow) was detected using the purified Pab.
  • IHC-P - DERL2 Antibody (C-term) AP8707b
    Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with DERL2 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - DERL2 Antibody (C-term) AP8707b
    DERL2 Antibody (C-term) (Cat.#AP8707b) FC analysis of MCF-7 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9GZP9
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 27567 Da
Antigen Region 191-218 aa
Additional Information
Gene ID 51009
Other Names Derlin-2, Degradation in endoplasmic reticulum protein 2, DERtrin-2, Der1-like protein 2, F-LAN-1, F-LANa, DERL2, DER2, FLANA
Target/Specificity This DERL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 191-218 amino acids from the C-terminal region of human DERL2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDERL2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DERL2
Synonyms DER2, FLANA
Function Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation.
Cellular Location Endoplasmic reticulum membrane; Multi- pass membrane protein
Tissue Location Ubiquitous. Overexpressed in various hepatocarcinomas.
Research Areas
Citations (0)

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Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. DERL2 is involved in the degradation of misfolded glycoproteins in the ER.


Lilley,, Nature 429 (6994), 834-840 (2004)

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$ 295.00
$ 99.00
Cat# AP8707b
(40 western blots)
Availability: In Stock
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