|Application ||WB, IHC-P, FC, E|
|Calculated MW||27567 Da|
|Antigen Region||191-218 aa|
|Other Names||Derlin-2, Degradation in endoplasmic reticulum protein 2, DERtrin-2, Der1-like protein 2, F-LAN-1, F-LANa, DERL2, DER2, FLANA|
|Target/Specificity||This DERL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 191-218 amino acids from the C-terminal region of human DERL2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DERL2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation.|
|Cellular Location||Endoplasmic reticulum membrane; Multi- pass membrane protein|
|Tissue Location||Ubiquitous. Overexpressed in various hepatocarcinomas.|
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Provided below are standard protocols that you may find useful for product applications.
Proteins that are unfolded or misfolded in the endoplasmic reticulum (ER) must be refolded or degraded to maintain the homeostasis of the ER. DERL2 is involved in the degradation of misfolded glycoproteins in the ER.
Lilley,B.N.et.al., Nature 429 (6994), 834-840 (2004)
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