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COTL1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - COTL1 Antibody (C-term) AP8819b
    Western blot analysis of COTL1 Antibody (C-term) (Cat. #AP8819b) in Hela cell line lysates (35ug/lane). COTL1 (arrow) was detected using the purified Pab.
  • IHC-P - COTL1 Antibody (C-term) AP8819b
    Formalin-fixed and paraffin-embedded human spleen tissue reacted with COTL1 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - COTL1 Antibody (C-term) AP8819b
    COTL1 Antibody (C-term) (Cat. #AP8819b) flow cytometry analysis of Hela cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
  • WB - COTL1 Antibody (C-term) AP8819b
    Western blot analysis of COTL1 (arrow) using rabbit polyclonal COTL1 Antibody (C-term) (Cat. #AP8819b). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the COTL1 gene.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14019
Other Accession Q2HJ57, NP_066972
Reactivity Human
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 15945 Da
Antigen Region 115-142 aa
Additional Information
Gene ID 23406
Other Names Coactosin-like protein, COTL1, CLP
Target/Specificity This COTL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-142 amino acids from the C-terminal region of human COTL1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCOTL1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name COTL1
Synonyms CLP
Function Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis.
Cellular Location Cytoplasm, cytoskeleton. Nucleus membrane; Peripheral membrane protein
Tissue Location Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas
Research Areas
Citations (0)

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COTL1 is one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis.


Provost,P.,, Proc. Natl. Acad. Sci. U.S.A. 96 (5), 1881-1885 (1999)
Provost,P.,, J. Biol. Chem. 276 (19), 16520-16527 (2001)

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$ 295.00
$ 99.00
Cat# AP8819b
(40 western blots)
Availability: In Stock
Bulk Size
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