|Application ||WB, FC, E|
|Calculated MW||52391 Da|
|Antigen Region||317-344 aa|
|Other Names||Selenium-binding protein 1, 56 kDa selenium-binding protein, SBP56, SP56, SELENBP1, SBP|
|Target/Specificity||This SELENBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 317-344 amino acids from the C-terminal region of human SELENBP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SELENBP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity).|
|Cellular Location||Nucleus. Cytoplasm, cytosol. Membrane; Peripheral membrane protein. Note=May associate with Golgi membrane. May associate with the membrane of autophagosomes (By similarity).|
|Tissue Location||Highly expressed in liver, lung, colon, prostate, kidney and pancreas. In brain, present both in neurons and glia (at protein level). Down-regulated in lung adenocarcinoma, colorectal carcinoma and ovarian cancer. Two-fold up-regulated in brain and blood from schizophrenia patients|
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Provided below are standard protocols that you may find useful for product applications.
SELENBP1 is the selenium-binding protein family. Selenium is an essential nutrient that exhibits potent anticarcinogenic properties, and deficiency of selenium may cause certain neurologic diseases. It has been proposed that the effects of selenium in preventing cancer and neurologic diseases may be mediated by selenium-binding proteins.
Kanazawa,T.,et.al., Schizophr. Res. 113 (2-3), 268-272 (2009)
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