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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   IL21 Antibody   

IL21 Antibody

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - IL21 Antibody AP8931a
    Western blot analysis of IL21 (Cat. #AP8931a) in MDA-MB435 cell line lysates (35ug/lane). IL21 (arrow) was detected using the purified Pab.
  • IHC-P - IL21 Antibody AP8931a
    Formalin-fixed and paraffin-embedded human breast carcinoma reacted with IL21 Antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - IL21 Antibody AP8931a
    IL21 Antibody (Cat.#AP8931a) flow cytometry analysis of MDA-MB231 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, FC, E
Primary Accession Q9HBE4
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 17923 Da
Additional Information
Gene ID 59067
Other Names Interleukin-21, IL-21, Za11, IL21
Target/Specificity This IL21 antibody is generated from rabbits immunized with human IL21.
Dilution WB~~1:1000
IHC-P~~1:10~50
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIL21 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL21
Function Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
Cellular Location Secreted.
Tissue Location Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes
Research Areas
Citations (0)

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Background

IL21 may promote the transition between innate and adaptive immunity. It induces the production of IgG(1) and IgG(3) in B-cells (By similarity). It may play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15 and may regulate proliferation of mature B-and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.

References

Sivakumar P.V.,et.al., Immunology 112:177-182(2004).

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$ 295.00
$ 99.00
Cat# AP8931a
Size:
Quantity:
(40 western blots)
Availability: In Stock
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